The airline BMI is to suspend daily flights between Glasgow and Heathrow from the end of March.
BMI said forthcoming rises in domestic passenger charges at Heathrow had made the loss-making route "unsustainable".
The airline, which employs 138 staff at Glasgow Airport, said a number of staff were now "at risk of redundancy".
Its decision to suspend the route means that from April, BA will be the only airline to provide flights between Glasgow and London Heathrow.
BMI said forthcoming rises in domestic passenger charges at Heathrow had made the loss-making route "unsustainable".
The airline, which employs 138 staff at Glasgow Airport, said a number of staff were now "at risk of redundancy".
Its decision to suspend the route means that from April, BA will be the only airline to provide flights between Glasgow and London Heathrow.
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